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Hea   Nikolai Evenkov Lazarov, MD, PhD, Professor
Publications
Lazarov N.E., Atanasova D.Y., Stavreva G.Ts. Immunohistochemical evidence for the presence of ATP-containing structures in the rat colon. Comp. rend. Acad. bulg. Sci. 65(11): 1613-1618, 2012   more...
Methods
- "On-line" registration of smooth muscle contractility in vitro - Computer-assisted image-analysis - Immunohistochemistry        more...
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Main research topics
According to the raise of neuro-degenerative diseases and dysfunctions of neural structures resulting in damage to vital systems in medical-biological aspect study the processes of making contact and exchange of sensor and effector information at different levels of organization of the nervous system. In our department we investigate the regulatory mechanisms of synaptic and nesinaptichni communications in central and autonomic nervous system; analyse neurotransmitter and neuromodulation interactions and the role of neuropeptides in normal and in models of pathological conditions such as hypoxia / ischemia, oxidative stress, Parkinson's disease, Alzheimer's disease, inflammation and others; clarify the etiopathogenesis of these social diseases provides opportunities for pharmacological interventions in their treatment; studied localization of neurotransmitters in the brain of tracing paths in the central nervous system development and in the aging brain structures; expression of the non-adrenergic, non-cholinergic transmitters along the "brain-gut" functional coordination of the contractile activity in the distal part of the gastrointestinal tract. Part of the research is associated with the study of endogenous bioactive peptides - etc. "Brain intestinal" neuropeptides (vasoactive intestinal peptide, ghrelin, somatostatin, neurotensin, and others). Investigates their effects and mechanisms of action of their protective role, interactions with other neurotransmitter systems in normal and pathological conditions.
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