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Dr. Monique Burrus Evolution & Diversite Biologique-EDB, Universite P. Sabatier - CNRS, 118, route de Narbonne - Bat IVR3, 31062 TOULOUSE cedex 4, France; www.edb.ups-tlse.fr/ Phone:(+33 5) 61 55 67 55; Fax: (+33 5) 61 55 73 27 E-mail: burrus@cict.fr Project duties: Administrative director of the project; Project management and coordination; Leader of Task 6: Training of young scientists; Reorganization of the labs of Partners 1&2 and standardization of lab procedures; Germplasm collection; Member of the IPR-Committee Research interests: biodiversity, genetic diversity, phylogeography, biotechnologies
Department of Applied Botany, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; www.bio.bas.bg/botany Phone: (+359 2) 979 70 07; (+359 2) 979 37 94; (+359 2) 979 21 83; Fax: (+359 2) 871 90 32; E-mail: maris@bio.bas.bg Project duties: Scientific director of the project (Partner 1); Project management and coordination; Leader of Task 1: Reorganization of the labs and standardization of lab procedures (planning and organisation of the new Biotechnological Laboratory of Medicinal Plants); Member of the IPR-Committee; Co-Leader of Task 4: In vitro cultivation (micropropagation and adaptation of plantlets to field conditions, alkaloid production by shoot-clump liquid cultures); Germplasm gathering from wild populations of L. aestivum Research interests: in vitro cultivation of plants (micropropagation, production of bioactive substances), ex situ conservation, medicinal plants, rare and threatened plants
Prof. DSc. Mladenka Paunova Ilieva-Stoilova Laboratory of Biotechnology and Industrial Microbiology, Institute of Microbiology, Bulgarian Academy of Sciences, 26 Maritza Blvd, 4002 PLOVDIV, Bulgaria; www.microbio.bas.bg Phone: (+359 2) 64 24 30; Fax: (+359 2) 44 01 02; E-mail: lbpmbas@plov.omega.bg Project duties: Co-director of the project (Partner 2); Project management and coordination; Reorganization of the labs and standardization of lab procedures; Co-Leader of Task 4: In vitro cultivation (callogenesis, alkaloid production by cell suspensions and callus-derived shoots); Research interests: in vitro plant systems, production of biologically active substances (optimization of biosynthetic processes, isolation, purification and identification of substances)
Prof. Dr. Christophe Clement Laboratoire de Stress, Defenses et Reproduction des Plantes, URVVC, UFR Sciences Exactes et Naturelles, URCA, BP 1089, 51687 REIMS Cedex 2, France; helios.univ-reims.fr/Labos/BPV/ Phone/Fax: (+33 3) 26 91 33 39; E-mail: christophe.clement@univ-reims.fr Project duties: Co-director of the project (Partner 4), Project management and coordination, Training of young scientists: in vitro cultivation of plants, hystological studies Research interests: in vitro cultivation of plants, plant physiology, plant deseases, biotic and abiotic stress in plants, androgenesis, male microspores
Prof. Dr. Michael Heinrich Department of Pharmaceutical & Biological Chemistry, The Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, WC1N 1AX, UK; www.ulsop.ac.uk/depts/cog-pages/phytotherapy.html Phone: 0044-(0)-20-7753-5844; Fax: 0044-(0)-20-7753-5909; E-mail: michael.heinrich@pharmacy.ac.uk Project duties: NATO consultant (from 2002) Research interests: anthropology, pharmacognosy / phytotherapy / natural product research (pharmaceutical biology) and ethnobotany
Dr. Gunther Hahne Institut de Biologie Moleculaire des Plantes, Strasbourg (2000-2001); Directeur du bureau regional du CNRS a Tokyo depuis 2004; www.ambafrance-jp.org/article-imprim.php3?id_article=378 E-mail: hahne@jp.cnrs.fr Project duties: NATO consultant (2000-2001) Research interests: plant physiology and biotechnology, molecular biology of plants Partner 1
Department of Applied Botany, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; www.bio.bas.bg/botany Phone: (+359 2) 979 21 53; Fax: (+359 2) 871 90 32; E-mail: chgussev@bio.bas.bg Project duties: Leader of Task 2: Germplasm gathering from wild populations; Project management; Planning and organisation of the new Biotechnological Laboratory of Medicinal Plants; Assesment and monitoring of wild populations of L. aestivum and collection of plant material of interest; In situ and ex situ studies; Creation of database on L. aestivum Research interests: floristics, conservation biology (in situ and ex situ conservation, protected areas, nature protection legislation), biodiversity, ethnobotany, medicinal plants, environmental risk assessment of GMO
Department of Applied Botany, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 70 07; (+359 2) 979 37 94; Fax: (+359 2) 871 90 32; E-mail: tds@bio.bas.bg Project duties: Leader of Task 3: Field cultivation and selection of L. aestivum; Project management and coordination; Reorganization of the experimental field plot and facilities and standardization of procedures; Collection of bulbs from wild population; In vivo cultivation and multiplication ; Studies on the effect of different parameters on biomass productivity and alkaloid conten; Selection of elite clones Research interests: cultivation and breeding of medicinal and aromatic plants, bioactive substances (essential oils, alkaloids), ethnobotany, in situ and ex situ conservation methods, plant propagation, environmental risk assessment of GMO
Department of Applied Botany, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 70 07; (+359 2) 979 37 94; Fax: (+359 2) 871 90 32; E-mail: juliboss@bio.bas.bg Project duties: Assistance in Project management and coordination, Planning and organisation of the new Biotechnological Laboratory of Medicinal Plants; Assesment and monitoring of wild populations of L. aestivum, Germplasm gathering, Creation of database on L. aestivum; In vivo cultivation and multiplication; Studies on the effect of different parameters on biomass productivity and alkaloid conten; Creation of the project home-page Research interests: medicinal and aromatic plants, in situ and ex situ conservation, environmental risk assessment of GMO, databases, digital photography, graphic design
Dr. Emil Molle Department of Boitechnology, Biological Faculty, Sofia University "St.Kliment Ochridski", Dragan Tzankov Str., 8, 1421 SOFIA, Bulgaria; www.uni-sofia.bg/faculties/biology Phone: (+359 2) 633 02 91; E-mail: mol@biofac.uni-sofia.bg Project duties: Mathematical modelling and experimental design; Biostatistics; Creation of the project home-page Research interests: biostatistics, models in genetics and biotechnology, biomathematics teaching Biotech group
Department of Applied Botany, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 70 07; (+359 2) 979 37 94; (+359 2) 979 21 83; Fax: (+359 2) 871 90 32; E-mail: julibogi@bio.bas.bg; Project duties: In vitro cultivation of L. aestivum: Initiation of clones originated from wild populations, Effect of growth regulators, Liquid shoot-clumps cultures; Standardization of lab procedures; Training in France in in vitro techniques and hystological observations; Research interests: botany, plant physiology and biotechnology, ex situ conservation, medicinal and aromatic plants, bioactive substances (essential oils, alkaloids), rare and threatened plants Teodora Ivanova, MSc (left) (from March 2003) Department of Applied Botany, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 70 07; (+359 2) 979 37 94; (+359 2) 979 21 83; Fax: (+359 2) 871 90 32; E-mail: tai@bio.bas.bg; Project duties: In vitro cultivation of L. aestivum: Enhancement and seasonal dynamics of micropropagaion, Ex vitro adaptation, Liquid shoot-clumps cultures; Standardization of lab procedures; Research interests: plant physiology and biotechnology, ex situ conservation, medicinal and aromatic plants, rare and threatened plants Lyubov Panayotova, MSc (right) (from October 2003) Department of Drug Toxicology, Institute of Physiology, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 21 17; (+359 2) 979 21 83; E-mail: astra13@bio.bas.bg; Project duties: In vitro cultivation of L. aestivum: Increase of galanthamine content, Effect of precursors, Alkaloids extraction, Liquid shoot-clumps cultures; Standardization of lab procedures; Research interests: plant physiology and biotechnology, phytochemistry, secondary metabolites, medicinal and aromatic plants, rare and threatened plants
Dr. Elena Genova Department of Applied Botany, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 37 58; Fax: (+359 2) 871 90 32; E-mail:elbio@bio.bas.bg Project duties: Adaptation of in vitro obtained plantlets to open-air conditions Research interests: botany, medicinal and aromatic plants (ecological, biological and phytocoenological characteristics), mapping and protection of rare and valuable medicinal plants, content and dynamics of bioactive substances: essential oils, tannins, saponins, flavonoids Analytical group
Department of Drug Toxicology, Institute of Physiology, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; www.bio.bas.bg/physiology Phone: (+359 2) 979 21 07; Phone/Fax: (+359 2) 873 84 69; E-mail: tox@bio.bas.bg Project duties: Leader of Task 5: Alkaloid determination (development of methods of identification and determination of Galanthamine and related alkaloids: TLC and HPLC); Reorganisation of the labs and standardization of lab procedures; Research interests: pharmacology, toxicology, pharmacokinetics and xenobiotic metabolism, drug interactions on the level of drug metabolism, therapeutic drug monitoring, clinical trials management Bozhidara Pandova, MSc (right) Department of Drug Toxicology, Institute of Physiology, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 21 17; (+359 2) 979 21 83; E-mail: darry@bio.bas.bg; Project duties: Determination of alkaloids by HPLC in L. aestivum plant material and in vitro cultures; Research interests: analytical chemistry, pharmacology, toxicology, pharmacokinetics and xenobiotic metabolism, phytochemistry, HPLC chromatography Kariology group
Department of Flora&Florogenesis, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 21 56; Fax: (+359 2) 871 90 32; E-mail:petrova@bio.bas.bg; Project duties: Reorganisation of the labs and standardization of lab procedures; Development of kariologycal techniques for L. aestivum; Research interests: biosystematics and taxonomy of higher plants (karyosystematics), biodiversity conservation, support of policy making Dr. Dessislava Dimitrova (right) Department of Flora&Florogenesis, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 21 60; Fax: (+359 2) 871 90 32; E-mail: desco@bio.bas.bg; Project duties: Development of kariologycal techniques using root-tips for L. aestivum; measurment of DNA content of L. aestivum; Research interests: biosystematics and taxonomy of higher plants (karyosystematics), DNA measurements, biodiversity conservation, support of policy making Pepa Stanimirova, MSc (left) Department of Flora&Florogenesis, Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev Str., 1113 SOFIA, Bulgaria; Phone: (+359 2) 979 21 57; Fax: (+359 2) 871 90 32; E-mail: pms@bio.bas.bg; Project duties: Karyological assessment of L. aestivum plants from wild populations; Control of kariological stability of in vitro obtained plants; Research interests: biosystematics and taxonomy of higher plants (karyosystematics), molecular taxonomy, biodiversity conservation Other participantsDr. Strahil Berkov (until December 2003)Department of Applied Botany, Institute of Botany, SOFIA, Bulgaria; Project involvement: Development of a rapid semi-quantitative TLC method for Gal evaluation in leaf extract of L. aestivum, Isolation of lycorine, Germplasm collection, training in France in in vitro techniques; micropropagation of L. aestivum Dimiter Uzunov, MSc (until June 2001) Institute of Botany, SOFIA, Bulgaria (recently Museo di Storia Naturale della Calabria ed Orto Botanico, Universita della Calabria, Arcavacata di Rende 87030, Italy); E-mail: duzunov@libero.it; Project involvement: Planning of Task 2: Germplasm gathering and assessment of natural populations of L. aestivum Dr. Iliana Damyanova-Kirilova (until April 2002) Soil Science & Agroecology Institute, SOFIA, Bulgaria; Project involvement: Soil sampling in natural populations of L. aestivum Partner 2
Laboratory of Biotechnology and Industrial Microbiology, Institute of Microbiology, Bulgarian Academy of Sciences, 26 Maritza Blvd, 4002 PLOVDIV, Bulgaria; www.microbio.bas.bg Phone: (+359 2) 64 24 30; Fax: (+359 2) 44 01 02; E-mail: lbpmbas@plov.omega.bg Project duties: In vitro cultivation of L. aestivum(callogenesis, alkaloid production by cell suspensions and callus-derived shoots); Reorganization of the labs and standardization of lab procedures; Training in France in in vitro techniques; Member of the IPR-Committee Research interests: in vitro plant systems; optimization of biosynthetic processes, isolation, purification and identification of bioactive substances; production of specific metabolites by: cell suspension (rosmarinic acid from Lavandula vera, enzymes (phosphohydrolases) from Nicotiana tabacum, polysaccharides from Helianthus annuus), hairy root cultures (betalains from Beta vulgaris, alkaloids from Datura stramonium), shoot cultures (alkaloids from L. aestivum )
Dr. Milen Georgiev (from May 2003 to July 2005) Laboratory of Biotechnology and Industrial Microbiology, Institute of Microbiology, Bulgarian Academy of Sciences, 26 Maritza Blvd, 4002 PLOVDIV, Bulgaria; E-mail: lbpmbas@plov.omega.bg Project duties: In vitro cultivation of L. aestivum (callogenesis, alkaloid production by cell suspensions and callus-derived shoots), adaptation of cell-cultures to submerged cultivation and their further cultivation in bioreactor; Research interests: production of plant secondary metabolites, bioreactor cultivation of plant in vitro cells, isolation and purification of biologically active substances
Vassil Georgiev, MSc (from May 2003) Laboratory of Biotechnology and Industrial Microbiology, Institute of Microbiology, Bulgarian Academy of Sciences, 26 Maritza Blvd, 4002 PLOVDIV, Bulgaria; E-mail: lbpmbas@plov.omega.bg Project duties: In vitro cultivation of L. aestivum, induction of callus of different plant origin, adaptation of callus-derived shoot cultures to submerged cultivation; Research interests: in vitro plant systems, production of secondary metabolites by plant cell, tissue and organ cultures: betalains from Beta vulgaris hairy root cultures; alkaloids from Datura stramonium hairy root cultures and Leucojum aestivum shoot cultures
Tatyana Gocheva, MSc (from October 2002) Laboratory of Biotechnology and Industrial Microbiology, Institute of Microbiology, Bulgarian Academy of Sciences, 26 Maritza Blvd, 4002 PLOVDIV, Bulgaria; E-mail: lbpmbas@plov.omega.bg Project duties: In vitro cultivation of L. aestivum, maintenance and bioreactor cultivation of in vitro cultures ; Research interests: plant biotechnology, in vitro plant systems, production of secondary metabolites Dr. Dimka Tuneva (from May 2003) Laboratory of Biotechnology and Industrial Microbiology, Institute of Microbiology, PLOVDIV, Bulgaria; (from 2002 in Germany) Project duties: In vitro cultivation of L. aestivum Petya Kovacheva, MSc (until October 2002) Laboratory of Biotechnology and Industrial Microbiology, Institute of Microbiology, PLOVDIV, Bulgaria; (from 2002 in Germany) Project duties: In vitro cultivation of L. aestivum, callogenesis, training in France in Galanthamine extraction and purification by CPC Partner 4
Laboratoire de Stress, Defenses et Reproduction des Plantes, URVVC, UFR Sciences Exactes et Naturelles, URCA, BP 1089, 51687 REIMS Cedex 2, France; helios.univ-reims.fr/Labos/BPV/ Phone/Fax: (+33 3) 26 91 34 41; E-mail: eric.courot@univ-reims.fr Project duties: Standardization of lab procedures; Training of young scientists from Partner 1&2 in in vitro techniques; Research interests: plant biotechnologies, bioproduction of secondary metabolites using cell, tissue and plant cultures: alkaloids (isoquinolines from Fagara zanthoxyloides and indole alkaloids from Catharanthus roseus), anthocyanins (Catharanthus roseus), terpenoids (Artemisia annua); elicitation on Vitis vinifera cell suspension for determination of chorismate mutase activity and its correlation with phenolic compound accumulation.
Dr. Jean-Hugues Renault Laboratoire de Isolement, Structure, Transformations et Synthese de Substances Naturelles, FRE CNRS 2715 , France; helios.univ-reims.fr/Labos/; E-mail: jh.renault@univ-reims.fr Project duties: Establishment of Centrifugal Partition Chromatography (CPC) method for L. aestivum alkaloids, purification of Galanthamine and related alkaloids; Training of young scientist from Partner 2 in Galanthamine extraction and purification by CPC; Research interests: pharmacy, pharmacognosy, isolation and purification of natural substances, chromatography Partner 3Savelina Shopova, MSc Pharm.R&D Director of Sopharma JFCo, R&D Division (former NIHFI - Chemical Pharmaceutical Research Institute), 3, Kliment Ohridski Blvd. 1797 SOFIA, Bulgaria, www.sopharma.bg, Phone: (+359 2) 74 41 75, Fax: (+359 2) 974 37 59; E-mail: nihfi@abv.bg Project involvement: (from 2004) Involved in the industrial transfer of scientific results after completion of the project Tihomir Ivanov, MSc Pharm. R&D Director of Sopharma P.L.C., 16, Iliensko Chaussee Str., 1220 SOFIA, Bulgaria www.sopharma.bg Project involvement: (2001-2003) Involved in the industrial transfer of scientific results after completion of the project Svetla Delcheva, MSc Group of Bioproducts, Department of Synthesis of Pharmaceutical Substances, R&D Division of Sopharma, Phone: (+359 2) 81 77 404, Project involvement: (from 2004) Member of the IPR Committee, Experience in microbiological biotechnology, In charge of scaling-up the cultivation of L. aestivum in vitro cultures offered by Partners 1 and 2 Boyan Baltiyski, MSc Group of Bioproducts, Department of Synthesis of Pharmaceutical Substances, R&D Division of Sopharma, Phone: (+359 2)) 81 77 403, Project involvement: (from 2004) Experience in microbiological biotechnology, Involved in scaling-up the cultivation of L. aestivum in vitro cultures Dr. Polina Stefanova Head of Central Microbiological Laboratory, R&D Division, Sopharma, Phone: (+359 2) 81 77 454, Project involvement: (from 2004) Expertize in microbiological test of the experimental in vitro cultures of L. aestivum Valentin Milenkov Group of Bioproducts, Department of Synthesis of Pharmaceutical Substances, R&D Division of Sopharma, Phone: (+359 2)) 81 77 403, Project involvement: (from 2004) Service of biotechnological facilities in NIHFI (Sopharma), involved in construction of bioreactors for scaling-up the experimental L. aestivum in vitro cultures Stilian Simeonov, MSc Pharm., Head of Analytical Laboratory, Sopharma Project involvement: (2001-2003) Qualitative and quantitative Gal analyses of L. aestivum in vitro cultures of interest supplied by Partners 1 and 2 Zorka Georgieva, MSc Pharm., Head of Phytochemical Laboratory, Sopharma Project involvement: (2001-2003) Expertize in Gal extraction, purification and isolation; economical, analytical and technological assessment of Gal production |
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